is approved for the treatment of major depressive disorder. for many, taking seroquel xr with an antidepressant was proven more effective for treating unresolved symptoms of depression than an antidepressant alone. call your doctor if you have unusual changes in mood, behavior,, or thoug. antidepressants can increase these in children, teens, and young adults. elderly dementia patients #taking seroquel xr have an increased riri of death. call your doctor if you have fever, stiff muscles, and confusion, as these may be signs of a life-threatening reaction or if you have uncontrollable muscle movements, as these could become permanent. high blood sugar has been reported with seroquel xr and medicines like it and in extreme cases can lead to coma or death. your doctor should check for cataracts. other risks include increased cholesterol and weight gain as well as seizures, dizziness on standing, drowsiness, impaired judgment and trouble swallowing and decreases "in white blood cells,, which can be fatal. use caution before driving or operating machinery.